Biological Sciences Seminar - Grant Flowers, PhD, Yale University, will present “Identifying genes essential for salamander limb regeneration".
Salamanders have unparalleled abilities to regenerate entire limbs, brain regions, and organs after injury, and the study of these abilities may provide insights toward human regenerative therapies. Recent advances in our understanding of the genome of one such species, the axolotl, combined with novel gene-editing techniques now permit the investigation of the molecular origins of these abilities. These tools have allowed us to assess the contributions of multiple low frequency cell lineages to the regenerating limb at once. Our comparisons reveal that regenerated limbs are high fidelity replicas of the originals even after repeated amputations. We are now applying these methods to carry out a high throughput screen to identify novel genes essential for limb regeneration.
Date: Friday, February 22, 2019
Time: 4:00 PM
Location: Sci B 133